Heteronuclei

MATERIALS SCIENCE BIOMEDICAL FOOD & AGRICULTURE HETERONUCLEI

MATERIALS SCIENCE

FFC NMR relaxometry has found applications in some key industries, such as oil and polymers, as well as in basic research. Herein are some examples of the most popular materials FFC applications.

Please contact Stelar if you would like information on any application not listed here or you would like to try a new application.

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BIOMEDICAL APPLICATIONS

FFC NMR relaxometry can offer a range of solutions in healthcare, pharmaceutical, cosmetic and preclinical and clinical research applications, in particular in biomedical detection with clinical MR imaging contrast agents.

Please contact Stelar if you would like information on any application not listed here or you would like to try a new application.

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FOOD & AGRICULTURE

FFC NMR relaxometry can offer solutions for the food and agriculture industries, particularly for quality control, shelf-life and denomination of origin. The NMRD profile is sensitive to dehydration, oxidation, spoilage, and the addition of additives including adulterants that may lead to fraudulent products Below are some examples of these applications.

Please contact Stelar if you would like information on any application not listed here or you would like to try a new application.

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HETERONUCLEI

FFC NMR relaxometry is mostly used for proton-based analyses (1H nucleus), as detailed in the other applications pages. It is however possible to study dispersion curves or simpler decay curves of T1 for other nuclei, such as deuterium (2H), fluorine (19F), lithium (7Li), compounds enriched in carbon-13 (13C) and more.

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Deuterium (2H):
Molecular dynamics in liquids and polymers

Measurement of deuterium relaxation rates could be important in understanding the amount of deuterium enrichment and exchange processes between deuterium nuclei and protons, which are often important for chemical mechanism studies. An in-house FFC NMR relaxometry study involving AIST Japan, looked into heavy water (D2O) relaxation rates in fuel cell membranes. The decay curves presented an evident multi-exponentiality particularly at low field.

A study has also been published using deuterium NMRD to elucidate molecular dynamics parameters in polymers. [ See ]


Lithium (7Li) and Fluorine (19F):
Electrolytes / catalyst layer materials for batteries & liquid crystals

Lithium is an important component of batteries in electronics industry. The fluorine nucleus is often found as part of the organic counter-ion of lithium-based electrolytes for batteries. The possibility to study the relaxation rates of these important nuclei could aid the studies for new battery electrolyte and electrode materials.

19F FFCR NMR has been applied to investigate the molecular dynamics of liquid crystals. [ See ]

NMRD profiles of three different nuclei (1H, 7Li and 19F), at 20°C, belonging to the same sample of an electrolyte solution for a battery system. From Stelar in-house data.

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Enriched Carbon (13C)
nuclei with low NMR sensitivity

13C NMRD profile of urea in water and a magnetization decay curve. From Stelar in-house data.

Molecular dynamics information on the 13C nucleus could be particularly important in studies of biomolecules, such as proteins, as well as for some carbon-containing synthetic materials.

A Stelar in-house study demonstrated, through 13C acquisition at low field, that FFC NMR relaxometry has the capacity to investigate the relaxometric behavior of low NMR-sensitive nuclei at low magnetic field strengths as well as at low temperatures (-120 °C).

It is possible to enhance the signal, by means of a method known as dynamic nuclear polarization (DNP), to enable detection of particularly insensitive heteronuclei such as 13C. (See: )